The sisyphus data can be downloaded and accessed in different ways:

MySQL

A MySQL dump of the database is available for download. Please register before download . [registration]
A graphical representation of the SISYPHUS database schema is also available from there. For help on how to set up MySQL databases and how to import mysql dumps, please consult the MySQL website.

FASTA

Each manually curated multiple alignment can be downloaded from the alignment main page as a fasta file via e.g here. The fasta header contains the information about the coresponding PDB regions.

DAS

The 3D representation of the alignment was computed from the curated alignment data using a Singular Value Decomposition. The derived data are available via the Distributed Annotation System (DAS) via e.g. http://sisyphus.mrc-cpe.cam.ac.uk/sisyphus/das/alignments/alignment?query=AL00050692.